Can CHADS2 Score Predict CV Risk, Mortality Among Patients Without AFib?
Baseline CHADS2 score is an independent risk factor for cardiovascular (CV) events and all-cause mortality among patients without atrial fibrillation (AF), according to findings of a new study.
“The association between CHADS2 score and stroke has been confirmed in patients with [AF]. But the majority of [CV] events occurred primarily in [the] population without [AF],” the researchers wrote. “Therefore, we performed this cohort study to evaluate the association between baseline CHADS2 score and [CV] events in the population without [AF].”
For up to 10 years, the researchers followed 99,755 adults from China who had complete baseline data. In turn, it was determined that the incidence of CV events (myocardial infarction [MI], cerebral infarction, or cerebral hemorrhage) and all-cause mortality had increased with CHADS2 score.
In fact, after adjusting for age, gender, and other conventional CV confounders, each 1-point increase in CHADS2 score was associated with the risk of all the outcomes.
The area under the receiver operating characteristic curve was calculated for each kind of outcome. Results were as follows:
- MI, 0.66
- Cerebral infarction, 0.67
- Cerebral hemorrhage, 0.66
- CV events, 0.67
- All-cause mortality, 0.69
The hazard ratio (95% confidence interval) was 1.17 (1.13-1.22) for CV event and 1.12 (1.08-1.15) for all-cause mortality.
—Colleen Murphy
Reference:
Ji C, Wu S, Shi J, et al. Baseline CHADS2 score and risk of cardiovascular events in the population without atrial fibrillation. Am J Cardiol. Published online June 3, 2020. doi:10.1016/j.amjcard.2020.05.035